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|Collectors:||Asheshov, Igor Nicholas, b. 1891.|
|Title:||Igor Nicholas Asheshov Records (RG5)|
|Quantity:||5.8 linear feet; 6 boxes|
|Call Phrase:||Asheshov (RG5)|
Igor Nicholas Asheshov (born, 1891) was a Russian bacteriologist and educator who specialized in research on bacterial viruses. Born in Russia 13 August 1891, he attended Prince Tenishev’s School in Petrograd, graduated in 1916 from the Saratov Imperial University, and did post-graduate work from 1918 to 1920 at the Central Bacteriological Laboratory of the Armies of South Russia where he conducted research on typhus. In 1928 the Government of British India invited him to take over d’Herelle’s research work on the cholera bacteriophage in India. In 1935 he became Research Officer for the Medical Research Council in London. After two years in this post he immigrated to Canada to join the Faculty of Medicine (Department of Bacteriology and Immunology) at the University of Western Ontario as Associate Professor.
Dr. Asheshov worked at the New York Botanical Garden from 1948 to 1953 as Bacteriologist-in-Charge of research on inhibition of bacterial viruses, under the direction of William Jacob Robbins. Asheshov directed experimental programs at the NYBG to isolate and identify bacteriophages (viruses that infect bacteria) in the search for substances to combat influenza, poliomyelitis (infantile paralysis), and other human diseases. In his research Asheshov screened cultures of microscopic fungi, like Aspergillus fumigatus and species of Streptomyces, and actinomycetes (filamentous bacteria) to develop antibiotics for use as therapeutic agents.
A critical part of Asheshov’s research was funded by grants from the National Foundation for Infantile Paralysis to find antibiotics to inhibit or destroy the polio virus. In this program he and his colleagues Marjorie Anchel, Helen Flon, Elizabeth A. Hall, Frederick Kavanaugh, and Freda Strelitz screened antibiotic chemicals grown in culture against a wide range of bacterial viruses and developed methods for their production. He directed tests of the antiviral Phagopedin sigma (fumagillin) and demonstrated its activity against a variety of streptococci bacilli. The team also isolated the antibiotics Phagolessin A58, Nybomycin, and Chrysomycin. Though these were not the final breakthrough in the search for a cure for polio, all were important contributions to the fields of bacteriology and antibiotic medicine.
Concurrent with his NYBG position, Asheshov held a faculty appointment at Columbia University as a Lecturer in Botany, teaching the course “The Biology of Bacterial Viruses.” At the cessation of funding by the National Foundation for Infantile Paralysis, he continued his work from 1953 to 1954 under a grant from the American Cancer Society. He then joined the Lister Institute for Preventive Medicine in London, England. Dr. Asheshov published over 40 scientific papers on bacteriology, seven of which relate to his research at the NYBG.
The Igor Nicholas Asheshov collection consists of correspondence, research and laboratory records, typescripts, photography, and progress reports of the National Foundation for Infantile Paralysis, covering the years of his association and research with the NYBG.
|The collection is organized into seven series:|
|Series 1: Correspondence. 1948-1953. Arranged alphabetically.|
|Series 2: Research Papers. 1948-1955. Arranged alphabetically.|
|Series 3: Typescripts. 1942-1958. Arranged alphabetically.|
|Series 4: Bacteriophage Group. 1949-1953. Arranged chronologically.|
|Series 5: Antiphage Group. 1951-1956. Arranged chronologically.|
|Series 6: National Foundation for Infantile Paralysis. 1947-1951. Arranged chronologically.|
|Series 7: Photography. Undated.|
This collection is open for research with permission from Mertz Library staff.
Requests for permission to publish material from the collection should be submitted in writing to the LuEsther T. Mertz Library of the New York Botanical Garden.
|The following terms have been used to index the description of this collection in the library's online public access catalog.|
|Robbins, William Jacob, 1890-|
|Asheshov, Igor Nicholas, 1891- -- Archives.|
|Antibiotics -- Research.|
|Bacteriology -- Research.|
|New York Botanical Garden Archives.|
|Poliomyelitis -- Research.|
New York Botanical Garden
RG5--William Jacob Robbins Records, 1918-1978
RG5--Marjorie Anchel Records, 1931-1978
Igor Nicholas Asheshov Records (RG5), Archives, The New York Botanical Garden.
This collection was transferred to the New York Botanical Garden Archives.
Originally processed by David Rose, Archives Assistant, September 1999. Converted to EAD in August 2006 by Kathleene Konkle under a grant from the National Endowment for the Humanities (NEH-PA 50678-04).
Series 1. Correspondence.
Scope and Content:
There are 59 files of correspondence with research associates at universities, pharmaceutical companies, government agencies, and the NYBG (Helen Flon, Elizabeth Hall, B. O. Dodge, William Robbins, and Freda Strelitz). Correspondents include Joshua Lederberg, Robert S. de Ropp, and Jonas Salk as well as pharmaceutical companies such as Pfizer, Lederle Laboratories, Merck, and Parke, Davis. Subject matter pertains to exchanges of culture strains, discussions of the epidemiology and biochemistry of diseases, and the production of antibiotics.
|1.1||Ackerman, W. Wilbur (re: methoxine)||ca. 1948-1953|
|1.2||Adams, Mark||ca. 1948-1953|
|1.3||Antibiotics & Chemotherapy||ca. 1948-1953|
|1.4||Re: Bacteriophage||ca. 1948-1953|
|1.5||Barnard, Robert D. to Freda Strelitz||ca. 1948-1953|
|1.6||Bieter, Raymond||ca. 1948-1953|
|1.7||Bogacz, John (Institut Pasteur)||ca. 1948-1953|
|1.8||Brown, Gordon C.||ca. 1948-1953|
|1.9||Burkholder, Paul R.||ca. 1948-1953|
|1.10||The Celon Company||ca. 1948-1953|
|1.11||Chain, E.||ca. 1948-1953|
|1.12||Chas. Pfizer & Company||ca. 1948-1953|
|1.13||Cherry, William (re: cholera phage)||ca. 1948-1953|
|1.14||Cowles, Philip B.||ca. 1948-1953|
|1.15||Duke, J. A.||ca. 1948-1953|
|1.16||Edwards, O. F. (re: cloacae phage)||ca. 1948-1953|
|1.17||Edwards, Philip R. (re: cholera phage)||ca. 1948-1953|
|1.18||Elford, W. J.||ca. 1948-1953|
|1.19||Flon, Helen||ca. 1948-1953|
|1.20||Friend, Charlotte||ca. 1948-1953|
|1.21||Galarneault, Thomas P. Jr.||ca. 1948-1953|
|1.22||Gillespie, Hazel||ca. 1948-1953|
|1.23||Greenberg, Joseph (re: chick malaria)||ca. 1948-1953|
|1.24||Groupe, Vincent||ca. 1948-1953|
|1.25||Hartman, Philip E.||ca. 1948-1953|
|1.26||Heald, C. B.||ca. 1948-1953|
|1.27||Heyden Chemical Corp.||ca. 1948-1953|
|1.28||Hoffmann-La Roche||ca. 1948-1953|
|1.29||Jevons, M. P.||ca. 1948-1953|
|1.30||Journal of Bacteriology||ca. 1948-1953|
|1.31||Kaiz, Gertrude||ca. 1948-1953|
|1.32||Kelner, Albert||ca. 1948-1953|
|1.33||Landerkin, G. B.||ca. 1948-1953|
|1.34||Lederberg, Joshua||ca. 1948-1953|
|1.35||Lederle Laboratories||ca. 1948-1953|
|1.36||Leifson, Einar||ca. 1948-1953|
|1.37||LoGrippo, Gerald A.||ca. 1948-1953|
|1.38||Mattas, Clyde L.||ca. 1948-1953|
|1.39||Merck & Company||ca. 1948-1953|
|1.40||Miscellaneous correspondence||ca. 1948-1953|
|1.41||Re: Moulds||ca. 1948-1953|
|1.42||National Research Council USA / screening agencies||ca. 1948-1953|
|1.43||National Research Council of Canada||ca. 1948-1953|
|1.44||Parke, Davis & Company||ca. 1948-1953|
|1.45||Periodical publications||ca. 1948-1953|
|1.46||Puck, Theodore T.||ca. 1948-1953|
|1.47||Radvin, I. S.||ca. 1948-1953|
|1.48||Rakeiten, Morris L.||ca. 1948-1953|
|1.49||Rawlins, T. E. (re: tobacco mosaic virus)||ca. 1948-1953|
|1.50||Reilly, Hilda Christine||ca. 1948-1953|
|1.51||Re: Reprints sent out on “Antibiotics active vs bacterial viruses”||ca. 1948-1953|
|1.52||Salk, Jonas E.||ca. 1948-1953|
|1.53||Scheicher & Schuell Company||ca. 1948-1953|
|1.55||Sobieski, Em. J.||ca. 1948-1953|
|1.56||Society of American Bacteriologists (2 files)||ca. 1948-1953|
|1.57||Spizizen, John||ca. 1948-1953|
|1.58||U. S. Department of Agriculture||ca. 1948-1953|
|1.59||Vogel, Peter||ca. 1948-1953|
|1.60||Woodruff, H. B.||ca. 1948-1953|
Series 2. Research Papers.
Scope and Content:
The research papers consist of 14 files relating to antibiotic substances, culture media, laboratory methods, and an index to bacteriological literature. There is 1 file of research notes on the experiments of Elizabeth A. Hall (1948-1950).
|1.62||Detergents on SF agar||ca. 1948-1955|
|1.63||Hall, E. A., research notes||August, 1948 – October, 1950|
|1.64||Index cards||ca. 1948-1955|
|1.65||Index to literature on bacteriology||ca. 1948-1955|
|1.66||Inoculating loop and sintered glass filters||ca. 1948-1955|
|1.68||Notes on antibiotic substances||ca. 1948-1955|
|1.69||Notes on antiviral agents||ca. 1948-1955|
|1.71||Pamphlets on media||ca. 1948-1955|
|1.72||Phegopedin sigma identity with fumagillin||ca. 1948-1955|
|2.2||Research papers, unidentified||ca. 1948-1955|
Series 3. Typescripts.
Scope and Content:
There are 9 files, three of which are typescripts of published articles and one of a copy of the doctoral dissertation (1942) of John Spizizen.
|1.73||“Action of 45 antibacterial substances on bacterial viruses” - Asheshov, Frelitz, and Hall||ca. 1942-1958|
|1.74||“Antibiotics against bacterial viruses”||ca. 1942-1958|
|1.75||Re: Bacteriophages and viruses||ca. 1942-1958|
|1.76||“Identity of fumagillin and phagopedin sigma”||ca. 1942-1958|
|1.77||“On flavo-coprinic L-3, H-2”||ca. 1942-1958|
|1.78||“Phagolessin A58, a new antibiotic active against bacterial viruses”||ca. 1942-1958|
|1.79||“Photodynamic pigment of some species of Elsinoe and Sphaceloma” - Weiss, Flon, & Berger||ca. 1942-1958|
|1.80||Ph. D. thesis of John Spizizen||1942|
|2.3||“On Fomes juniperinus”||ca. 1942-1958|
Series 4. Bacteriophage Group.
Scope and Content:
There are 7 files of experimental data on “Active Actinomycetes” and “Inactive Actinomycetes.” All contain a numbered series of tables of laboratory records of bacteriophage experiments presenting information on culture strains, media, and chronological progress.
|2.4||Active Actinomycetes: A019 – A325||ca. 1949-1953|
|2.5||Active Actinomycetes: A331 – A497||ca. 1949-1953|
|2.6||Active Actinomycetes: A505 – A700||ca. 1949-1953|
|2.7||Active Actinomycetes: A703 – A944||ca. 1949-1953|
|3.1||Active Actinomycetes: A951 – A1072||ca. 1949-1953|
|3.2||Active Actinomycetes: A1074 – A1220||ca. 1949-1953|
|3.3||Active Actinomycetes, unidentified||ca. 1949-1953|
|3.4||Inactive Actinomycetes||ca. 1949-1953|
|3.5||January, 1951 – 30 June 1951|
|3.6||January, 1951 – 30 June 1951|
|4.1||Jan, 1949 – May, 1949|
|4.2||Jan, 1949 – May, 1949|
|4.3||May, 1949 – Oct, 1949|
|4.4||Oct, 1949 – Dec, 1949|
|4.5||1 Jan 1950 – 30 June 1950, Parts I, II, III|
|4.6||1 Jan 1950 – 30 June 1950, Parts I, II, III|
|4.7||1 Jan 1950 – 30 June 1950, Parts I, II, III|
|4.8||Mould A58, Feb, 1950 – April, 1950|
|4.9||July, 1950 – Jan, 1951|
|4.10||Jan, 1951 – 30 June 1951|
|4.11||July, 1951 – Jan, 1952|
|4.12||Jan, 1952 – July, 1952|
|4.13||July, 1952 – Jan, 1953|
|4.14||Jan, 1953 – July, 1953|
Series 5. Antiphage Group.
Scope and Content:
There are 34 files of experiment data consisting of tables formerly collected in loose-leaf notebooks. Some files are titled with experiment numbers. There are three subject files dealing with various fungi.
|4.15||586 . . . 828||1944|
|4.18||837 / 32-71||1947|
|5.8||419, Freda Strelitz notes||n.d.|
|5.11||Fungi / cultures||n.d.|
Series 6. National Foundation for Infantile Paralysis.
Scope and Content:
There are 11 files of abstracts of bi-annual progress reports issued by the National Foundation for Infantile Paralysis, Inc. to its Committee on Virus Research & Epidemiology which comprised all NFIP participant institutions that were grantees (indexed by grant number) engaged in polio research. As a grantee, the NYBG (grant number CVRE #70) is listed in each index with reference to its abstract within. Summary reports of Asheshov’s research are filed under “NYBG” and “William J. Robbins.” The reports contain information on experiments, antiphage action, antibiotic surveys, chemical studies, and antibiotic production. There is one report on cancer research and two files on conferences relating to Asheshov’s research findings.
|5.13||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.14||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.15||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.16||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.17||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.18||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.19||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.20||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|5.21||Abstracts of Progress Reports||July, 1947 – Dec, 1951|
|6.1||Abstracts of Progress Reports||Jan, 1952 – June, 1953|
|6.2||Abstracts of Progress Reports||Jan, 1952 – June, 1953|
|6.3||Abstracts of Progress Reports||Jan, 1952 – June, 1953|
|6.4||Progress report: Cancer chemotherapy and … anti-cancer agents, Southern Research Inst.||1952|
|6.5||Conference on chemoprophylaxis … and … poliomyelitis, Univ Michigan||14-15 Feb 1952|
|6.6||Conference on virus and rickettsial classification and nomenclature||1952|
Series 7. Photography.
Scope and Content:
There is one file of mounted photos relating to an article published in the American Journal of Botany by Robert S. de Ropp of Lederle Laboratories.
|6.7||Re: R. S. de Ropp, American Journal of Botany||n.d.|