The present study offers an overall outline of the behavior of epiphytic angiosperms in Cuba, based on literature, herbarium materials (HAC), field observations and personal communication from specialists. The characteristics considered were: endemism, geographic distribution in Cuba and worldwide, distribution within the vegetation units, and variants of epiphytism. A total of 310 epiphytic angiosperm species belonging to 14 families were compiled. The Orchidaceae have the greatest number number of species (208), followed by the Bromeliaceae and Piperaceae (Peperomia). In regard to endemism, the Orchidaceae are also the leading family, followed by Piperaceae (Peperomia). All epiphytic variants considered by Kress (1986) are present in Cuban epiphytic angiosperms. The Cuban epiphytic angiosperm flora has a strong relation with the epiphytic angiosperm flora of the other Greater Antillean islands. An analysis based on the behavior of the main angiosperm families with epiphytic species (Araceae, Bromeliaceae, Cactaceae, Piperaceae and Orchidaceae) in the Greater Antilles was performed, taking into account species richness, and percentages of common species and endemism.